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Results: In the tumor region, the MnO x shell is quickly decomposed to produce Mn 3+ and oxygen (O 2) to directly generate singlet oxygen ( 1O 2). Furthermore, the in vivo biodistribution, imaging and therapy were studied by U87MG tumor-bearing mice. We also evaluated the tumor cell-killing mechanism by detection of reactive oxygen (ROS), lipid peroxidation and mitochondrial membrane potential changes in vitro. Enhanced XEPL and magnetic resonance (MR) imaging were investigated by the decomposition of MnO x shell in the environment of tumors. Methods: Herein, we report Mn 3+-rich manganese oxide (MnO x)-coated chromium-doped zinc gallogermanate (ZGGO) nanoparticles (Mn-ZGGOs). However, optical imaging still suffers from limited for high spatial resolution.
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X-ray excited persistent luminescence (XEPL) imaging has attracted increasing attention in biomedical imaging due to elimination of autofluorescence, high signal-to-noise ratio and repeatable activation with high penetration. Select the file that you have just downloaded and select import option Reference Manager (RIS).
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Available fromĬlick on Go to download the file. Mn 3+-rich oxide/persistent luminescence nanoparticles achieve light-free generation of singlet oxygen and hydroxyl radicals for responsive imaging and tumor treatment. Departments of Diagnostic Radiology and Surgery, Clinical Imaging Research Centre, Centre for Translational Medicine, Nanomedicine Translational Research Program, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, Departments of Chemical and Biomolecular Engineering, and Biomedical Engineering, Faculty of Engineering, National University of Singapore, Singapore.ĭing D, Feng Y, Qin R, Li S, Chen L, Jing J, Zhang C, Sun W, Li Y, Chen X, Chen H. Department of Radiation Oncology, Cancer Center, the First Affiliated Hospital of Xiamen University, Xiamen 361003, China.ģ. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.Ģ.
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Research Paper Mn 3+-rich oxide/persistent luminescence nanoparticles achieve light-free generation of singlet oxygen and hydroxyl radicals for responsive imaging and tumor treatmentĭandan Ding 1, Yushuo Feng 1, Ruixue Qin 1, Shi Li 1, Lei Chen 1, Jinpeng Jing 1, Chutong Zhang 1, Wenjing Sun 1, Yimin Li 2, Xiaoyuan Chen 3, Hongmin Chen 1ġ.